The concurrence of DNA methylation and demethylation is associated with transcription regulation

Jiejun Shi; Jianfeng Xu; Yiling Elaine Chen; Jason Sheng Li; Ya Cui; Lanlan Shen; Jingyi Jessica Li; Wei Li

doi:10.1038/s41467-021-25521-7

Nature Communications (Sep 2021)

The concurrence of DNA methylation and demethylation is associated with transcription regulation

Jiejun Shi,
Jianfeng Xu,
Yiling Elaine Chen,
Jason Sheng Li,
Ya Cui,
Lanlan Shen,
Jingyi Jessica Li,
Wei Li

Affiliations

Jiejun Shi: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine
Jianfeng Xu: Department of Molecular and Cellular Biology, Baylor College of Medicine
Yiling Elaine Chen: Department of Statistics, University of California
Jason Sheng Li: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine
Ya Cui: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine
Lanlan Shen: Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center
Jingyi Jessica Li: Department of Statistics, University of California
Wei Li: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine

DOI: https://doi.org/10.1038/s41467-021-25521-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The global pattern of the mammalian methylome is formed by changes in methylation and demethylation. Here the authors describe a metric methylation concurrence that measures the ratio of unmethylated CpGs inside the partially methylated reads and show that methylation concurrence is associated with epigenetically regulated tumour suppressor genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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