ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells

Dasol Han; Guojing Liu; Yujeong Oh; Seyoun Oh; Seungbok Yang; Lori Mandjikian; Neha Rani; Maria C. Almeida; Kenneth S. Kosik; Jiwon Jang

doi:10.1038/s41467-023-36178-9

Nature Communications (Feb 2023)

ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells

Dasol Han,
Guojing Liu,
Yujeong Oh,
Seyoun Oh,
Seungbok Yang,
Lori Mandjikian,
Neha Rani,
Maria C. Almeida,
Kenneth S. Kosik,
Jiwon Jang

Affiliations

Dasol Han: Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California
Guojing Liu: Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California
Yujeong Oh: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
Seyoun Oh: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
Seungbok Yang: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
Lori Mandjikian: Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California
Neha Rani: Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California
Maria C. Almeida: Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California
Kenneth S. Kosik: Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California
Jiwon Jang: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)

DOI: https://doi.org/10.1038/s41467-023-36178-9
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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The metastability of stem cells requires a mechanism for actively blocking dedifferentiation to achieve successful differentiation. Here the authors show that ZBTB12 serves as a molecular barrier to dedifferentiation by repressing a primate-specific retrotransposon, HERVH.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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