C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens

Shouyong Ju; Hanqiao Chen; Shaoying Wang; Jian Lin; Yanli Ma; Raffi V. Aroian; Donghai Peng; Ming Sun

doi:10.1038/s42003-022-03589-1

Communications Biology (Jun 2022)

C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens

Shouyong Ju,
Hanqiao Chen,
Shaoying Wang,
Jian Lin,
Yanli Ma,
Raffi V. Aroian,
Donghai Peng,
Ming Sun

Affiliations

Shouyong Ju: State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University
Hanqiao Chen: State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University
Shaoying Wang: State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University
Jian Lin: State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University
Yanli Ma: State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University
Raffi V. Aroian: Program in Molecular Medicine, University of Massachusetts Chan Medical School Worcester
Donghai Peng: State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University
Ming Sun: State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University

DOI: https://doi.org/10.1038/s42003-022-03589-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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Bacillus thuringiensis toxin Cry5Ba triggers potassium ion leakage, causing mitochondrial damage and energy imbalance. C. elegans can monitor this intracellular energy imbalance via AMP-activated protein kinase to trigger innate immune responses.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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