Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility

Fuxin Jiao; Xiaoming Hu; Hanrui Yin; Feixiang Yuan; Ziheng Zhou; Wei Wu; Shanghai Chen; Zhanju Liu; Feifan Guo

doi:10.1038/s42003-023-04425-w

Communications Biology (Jan 2023)

Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility

Fuxin Jiao,
Xiaoming Hu,
Hanrui Yin,
Feixiang Yuan,
Ziheng Zhou,
Wei Wu,
Shanghai Chen,
Zhanju Liu,
Feifan Guo

Affiliations

Fuxin Jiao: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Xiaoming Hu: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Hanrui Yin: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Innovation Center for Intervention of Chronic Disease and Promotion of Health, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Feixiang Yuan: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Ziheng Zhou: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Innovation Center for Intervention of Chronic Disease and Promotion of Health, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Wei Wu: Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University
Shanghai Chen: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Zhanju Liu: Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University
Feifan Guo: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University

DOI: https://doi.org/10.1038/s42003-023-04425-w
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 10

Abstract

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Chronic restraint stress induces anxiety-like behaviors and colitis susceptibility, which is mediated by c-Jun in AgRP neurons.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal