SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

Maria Clara Saad Menezes; Diego Vinicius Santinelli Pestana; Gustavo Rosa Gameiro; Luiz Fernando Ferraz da Silva; Ėlodie Baron; Jean-Jacques Rouby; José Otavio Costa Auler Jr

doi:10.1186/s13054-020-03399-z

Critical Care (Feb 2021)

SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

Maria Clara Saad Menezes,
Diego Vinicius Santinelli Pestana,
Gustavo Rosa Gameiro,
Luiz Fernando Ferraz da Silva,
Ėlodie Baron,
Jean-Jacques Rouby,
José Otavio Costa Auler Jr

Affiliations

Maria Clara Saad Menezes: Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
Diego Vinicius Santinelli Pestana: Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
Gustavo Rosa Gameiro: Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
Luiz Fernando Ferraz da Silva: Department of Pathology, Faculdade de Medicina, Universidade de Sao Paulo
Ėlodie Baron: Multidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance-Publique-Hôpitaux-de-Paris, Sorbonne University
Jean-Jacques Rouby: Multidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance-Publique-Hôpitaux-de-Paris, Sorbonne University
José Otavio Costa Auler Jr: Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo

DOI: https://doi.org/10.1186/s13054-020-03399-z
Journal volume & issue: Vol. 25, no. 1
pp. 1 – 13

Abstract

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Abstract The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.

Published in Critical Care

ISSN: 1364-8535 (Print); 1466-609X (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Medical emergencies. Critical care. Intensive care. First aid
Website: https://ccforum.biomedcentral.com/

About the journal

Abstract

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