Frontiers in Oncology (Feb 2019)
The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management
- Khalid O. Alfarouk,
- Khalid O. Alfarouk,
- Khalid O. Alfarouk,
- Khalid O. Alfarouk,
- Adil H. H. Bashir,
- Adil H. H. Bashir,
- Ahmed N. Aljarbou,
- Ahmed N. Aljarbou,
- AbdelRahman M. Ramadan,
- Abdel Khalig Muddathir,
- Abdel Khalig Muddathir,
- Sari T. S. AlHoufie,
- Sari T. S. AlHoufie,
- Abdelhamid Hifny,
- Gamal O. Elhassan,
- Muntaser E. Ibrahim,
- Saad S. Alqahtani,
- Shakir D. AlSharari,
- Shakir D. AlSharari,
- Claudiu T. Supuran,
- Cyril Rauch,
- Rosa Angela Cardone,
- Stephan J. Reshkin,
- Stefano Fais,
- Salvador Harguindey
Affiliations
- Khalid O. Alfarouk
- Alfarouk Biomedical Research LLC, Tampa, FL, United States
- Khalid O. Alfarouk
- Hala Alfarouk Cancer Center, Khartoum, Sudan
- Khalid O. Alfarouk
- Al-Ghad International College for Applied Medical Sciences, Medina, Saudi Arabia
- Khalid O. Alfarouk
- American Biosciences, Inc., New York City, NY, United States
- Adil H. H. Bashir
- Hala Alfarouk Cancer Center, Khartoum, Sudan
- Adil H. H. Bashir
- Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
- Ahmed N. Aljarbou
- College of Pharmacy, Qassim University, Buraydah, Saudi Arabia
- Ahmed N. Aljarbou
- Al-Ghad International College for Applied Medical Sciences, Jeddah, Saudi Arabia
- AbdelRahman M. Ramadan
- College of Dentistry, Taibah University, Medina, Saudi Arabia
- Abdel Khalig Muddathir
- Hala Alfarouk Cancer Center, Khartoum, Sudan
- Abdel Khalig Muddathir
- Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan
- Sari T. S. AlHoufie
- Al-Ghad International College for Applied Medical Sciences, Medina, Saudi Arabia
- Sari T. S. AlHoufie
- 0Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia
- Abdelhamid Hifny
- 1Al-Azhar University, Cairo, Egypt
- Gamal O. Elhassan
- 2Unaizah College of Pharmacy, Qassim University, Unaizah, Saudi Arabia
- Muntaser E. Ibrahim
- Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
- Saad S. Alqahtani
- 3Clinical Pharmacy Department, College of pharmacy, Jazan University, Jazan, Saudi Arabia
- Shakir D. AlSharari
- 4Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
- Shakir D. AlSharari
- 5Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States
- Claudiu T. Supuran
- 6University of Florence, Florence, Italy
- Cyril Rauch
- 7School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom
- Rosa Angela Cardone
- 8Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy
- Stephan J. Reshkin
- 8Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy
- Stefano Fais
- 9Department of Oncology and Molecular Medicine, National Institute of Health, Rome, Italy
- Salvador Harguindey
- 0Institute for Clinical Biology and Metabolism, Vitoria, Spain
- DOI
- https://doi.org/10.3389/fonc.2019.00075
- Journal volume & issue
-
Vol. 9
Abstract
Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP inducing gastric cancer offers the potential strategy in the managing of HP rather than eradicating it. In this article, we try to summarize the biology of HP-induced gastric cancer and discuss the current pharmacological approach to treat and prevent its carcinogenicity.
Keywords
