Oxidative Stress Evaluation of Lambda-Cyhalothrin and Antioxidant (Vitamin E) on Male Rats

Abstract

Background:Lambda-cyhalothrin (LCT) is a widely used pyrethroid to control insect pests in agriculture, public health, and homes. Objectives:The aim of this study was to evaluate the oxidative stress evaluation of LCT pesticides and and antioxidants (vitamin E) in male rats. Materials and Methods:Thirty adult male rats were separated evenly into three groups after 3 weeks of acclimatization as follows: For 12 weeks, group-normal C’s feed and water were given to 10 rats. Group T was given LCT at a dose of 0.5 mL per 100 g of body weight for 12 weeks (n = 10 rats) and group E was given (LC + vitamin E) at a dose of 0.5 mL per 100 g of body weight. Results:At a results significant increase in malondialdehyde (MDA) level in the T group compared with the E group and C group. Significant decrease of glutathione (GSH) levels in the T group compared with the E group and C group. Macroscopic and microscopic lesions demonstrated atrophy of the kidney in the T group and congestion in the G group while the C group was normal the microscopic lesion of the kidney in the T group multiplied the area of the renal cast at renal tubules with degenerative changes and multiply the area of hemorrhage at the interstitial area but E group show mild degenerative changes in the structure of the renal tubule. It is interesting to note that every modification showed how detrimental LTC is to the kidneys and how vitamin E’s antioxidant capacity benefits them. Conclusions:Exposure to pesticides continuously creates a health concern, particularly in the agricultural working environment where animal and human life are intertwined. Thus, the study findings demonstrate the impact of LCT on oxidative stress and renal function as well as the antioxidant role of vitamin E.

Keywords

• kidney
• lambda-cyhalothrin
• rats
• vitamin e