Evaluation of Liver Biopsy Results in Chronic Hepatitis B Patients

Abstract

INTRODUCTION: Our country is a middle endemic country in terms of chronic hepatitis B and is an important problem in my region. In this study, we examined patients who underwent liver biopsy due to chronic hepatitis B. METHODS: We included a total of 653 patients who underwent liver biopsy for CHB between October 2011 and March 2019 in our hospital. Demographic data such as age, sex, alanine aminotransferase (ALT), aspartate aminotrabsferase (AST), HBeAg, Anti-HBe, HBV DNA levels were obtained from hospital automation recording system and liver biopsy results were obtained from pathology recording system. RESULTS: A total of 600 CHB patients who underwent liver biopsy were included in the study. 216 (6) of the patients were female and the mean age was 32.5 +- 1.25 (15-78). The mean ALT value was 56.6 +- 5.42 (9-445) U / L, the mean fibrosis value was 1.6 +- 1.1 (0-6) and the HBV DNA level was 119840000 +- 483761000 IU / ml. The number of patients with normal ALT (<32 U / L) was 301 (50.1%). The pathology of 188 (31.3%) of these patients was fibrosis ≥2 and / or HAI≥6 and treatment was started. DISCUSSION AND CONCLUSION: In conclusion, liver biopsy is still the gold standard in chronic hepatitis B patients and should be considered in patients with high HBV DNA, even if ALT is normal.

Keywords

• liver biopsy
• chronic hepatitis b
• knodell classification