Influence of phytomelatonin on immune cell function in male golden hamsters

Abstract

BACKGROUND: An assortment of plant animal groups incorporates phytomelatonin, shows the similar pattern as in animals recommending its capacity can be closely resemble animals as in plants. AIMS AND OBJECTIVES: An in vivo research work needed to explore the impact of dietary phytomelatonin, i.e., the cabbage and carrot, on immune cell functions in a male rodent golden hamster (Mesocricetus auratus). MATERIALS AND METHODS: In this study, we examined the general immune response (spleen weight, total leukocyte count, and % lymphocyte), delayed type hypersensitivity (DTH) response, the blastogenic response of peripheral blood mononuclear cell (PBMC), splenocytes, and bone marrow mononuclear cell proliferation in terms of granulocyte macrophage colony forming unit (GM CFU) count, as an indicator of bone marrow macrophages. RESULTS: An increased circulatory melatonin level due to melatonin supplemented diet enhanced the total leukocyte count, % lymphocyte count, a proliferation of splenocytes, PBMCs, GM CFU count, % DTH response, and serum cytokine (interleukin 2 and interferon γ) production. CONCLUSION: A correlation study recommended that incited serum melatonin is emphatically corresponded with the improvement of the safe status of hamsters. In this way, our information infers that dietary melatonin may impact resistance on account of its high selectivity and sensitivity. Thus, it could be suggested that the dietary phytomelatonin might be one of the strong restorative procedures to enhance the immune responses for better well being of a person at its any age of life.

Keywords

• bone marrow mononuclear cells
• cytokines
• immunity
• phytomelatonin
• t-cells