Nature Communications (Jul 2018)
Stromal PTEN determines mammary epithelial response to radiotherapy
- Gina M. Sizemore,
- Subhasree Balakrishnan,
- Katie A. Thies,
- Anisha M. Hammer,
- Steven T. Sizemore,
- Anthony J. Trimboli,
- Maria C. Cuitiño,
- Sarah A. Steck,
- Gary Tozbikian,
- Raleigh D. Kladney,
- Neelam Shinde,
- Manjusri Das,
- Dongju Park,
- Sarmila Majumder,
- Shiva Krishnan,
- Lianbo Yu,
- Soledad A. Fernandez,
- Arnab Chakravarti,
- Peter G. Shields,
- Julia R. White,
- Lisa D. Yee,
- Thomas J. Rosol,
- Thomas Ludwig,
- Morag Park,
- Gustavo Leone,
- Michael C. Ostrowski
Affiliations
- Gina M. Sizemore
- The Comprehensive Cancer Center, The Ohio State University
- Subhasree Balakrishnan
- The Comprehensive Cancer Center, The Ohio State University
- Katie A. Thies
- Hollings Cancer Center, Medical University of South Carolina
- Anisha M. Hammer
- The Comprehensive Cancer Center, The Ohio State University
- Steven T. Sizemore
- The Comprehensive Cancer Center, The Ohio State University
- Anthony J. Trimboli
- Hollings Cancer Center, Medical University of South Carolina
- Maria C. Cuitiño
- Hollings Cancer Center, Medical University of South Carolina
- Sarah A. Steck
- The Comprehensive Cancer Center, The Ohio State University
- Gary Tozbikian
- Department of Pathology, The Ohio State University Wexner Medical Center
- Raleigh D. Kladney
- The Comprehensive Cancer Center, The Ohio State University
- Neelam Shinde
- The Comprehensive Cancer Center, The Ohio State University
- Manjusri Das
- The Comprehensive Cancer Center, The Ohio State University
- Dongju Park
- The Comprehensive Cancer Center, The Ohio State University
- Sarmila Majumder
- The Comprehensive Cancer Center, The Ohio State University
- Shiva Krishnan
- The Comprehensive Cancer Center, The Ohio State University
- Lianbo Yu
- Department of Biomedical Informatics’ Center for Biostatistics, The Ohio State University
- Soledad A. Fernandez
- Department of Biomedical Informatics’ Center for Biostatistics, The Ohio State University
- Arnab Chakravarti
- The Comprehensive Cancer Center, The Ohio State University
- Peter G. Shields
- The Comprehensive Cancer Center, The Ohio State University
- Julia R. White
- The Comprehensive Cancer Center, The Ohio State University
- Lisa D. Yee
- Division of Surgical Oncology, Department of Surgery, City of Hope
- Thomas J. Rosol
- Department of Molecular and Cellular Biology, College of Arts and Sciences, Ohio University
- Thomas Ludwig
- The Comprehensive Cancer Center, The Ohio State University
- Morag Park
- Rosalind and Morris Goodman Cancer Research Centre, McGill University
- Gustavo Leone
- Hollings Cancer Center, Medical University of South Carolina
- Michael C. Ostrowski
- Hollings Cancer Center, Medical University of South Carolina
- DOI
- https://doi.org/10.1038/s41467-018-05266-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperplasia.
