Stimulating the sir2–spargel axis rescues exercise capacity and mitochondrial respiration in a Drosophila model of Barth syndrome

• Deena Damschroder,
• Rubén Zapata-Pérez,
• Kristin Richardson,
• Frédéric M. Vaz,
• Riekelt H. Houtkooper,
• Robert Wessells

Affiliations

Deena Damschroder

Wayne State University School of Medicine, Department of Physiology, Detroit, MI 48201, USA

Rubén Zapata-Pérez

Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Emma Children's Hospital, Meibergdreef 9, Amsterdam 1105AZ, The Netherlands

Kristin Richardson

Wayne State University School of Medicine, Department of Physiology, Detroit, MI 48201, USA

Frédéric M. Vaz

Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Emma Children's Hospital, Meibergdreef 9, Amsterdam 1105AZ, The Netherlands

Riekelt H. Houtkooper

Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Emma Children's Hospital, Meibergdreef 9, Amsterdam 1105AZ, The Netherlands

Robert Wessells

Wayne State University School of Medicine, Department of Physiology, Detroit, MI 48201, USA