Nature Communications (Jul 2020)

Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment

  • Robert W. Cross,
  • Zachary A. Bornholdt,
  • Abhishek N. Prasad,
  • Joan B. Geisbert,
  • Viktoriya Borisevich,
  • Krystle N. Agans,
  • Daniel J. Deer,
  • Kevin Melody,
  • Karla A. Fenton,
  • Heinz Feldmann,
  • Armand Sprecher,
  • Larry Zeitlin,
  • Thomas W. Geisbert

DOI
https://doi.org/10.1038/s41467-020-17446-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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During an ongoing Ebola virus outbreak, infection before onset of protective immunity from vaccination is a possible scenario. Here the authors show in non-human primates that vaccination shortly before treatment with a monoclonal antibody does not negatively affect effectiveness of the antibody therapy.