7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity

Opsenica Igor; Terzić Nataša A.; Opsenica Dejan M.; Milhous Wilbur K.; Šolaja Bogdan A.

doi:10.2298/JSC0411919O

Journal of the Serbian Chemical Society (Jan 2004)

7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity

Opsenica Igor,
Terzić Nataša A.,
Opsenica Dejan M.,
Milhous Wilbur K.,
Šolaja Bogdan A.

Affiliations

Opsenica Igor: Institute of Chemistry, Technology and Metallurgy, Belgrade, Serbia and Montenegro
Terzić Nataša A.: Institute of Chemistry, Technology and Metallurgy, Belgrade, Serbia and Montenegro
Opsenica Dejan M.: Institute of Chemistry, Technology and Metallurgy, Belgrade, Serbia and Montenegro
Milhous Wilbur K.: Devision of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, USA
Šolaja Bogdan A.: Faculty of Chemistry, Belgrade

DOI: https://doi.org/10.2298/JSC0411919O
Journal volume & issue: Vol. 69, no. 11
pp. 919 – 922

Abstract

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Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin.

Published in Journal of the Serbian Chemical Society

ISSN: 0352-5139 (Print); 1820-7421 (Online)
Publisher: Serbian Chemical Society
Country of publisher: Serbia
LCC subjects: Science: Chemistry
Website: http://www.shd-pub.org.rs/index.php/JSCS

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