Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

Simona Infantino; Amanda Light; Kristy O’Donnell; Vanessa Bryant; Danielle T. Avery; Michael Elliott; Stuart G. Tangye; Gabrielle Belz; Fabienne Mackay; Stephane Richard; David Tarlinton

doi:10.1038/s41467-017-01009-1

Nature Communications (Oct 2017)

Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

Simona Infantino,
Amanda Light,
Kristy O’Donnell,
Vanessa Bryant,
Danielle T. Avery,
Michael Elliott,
Stuart G. Tangye,
Gabrielle Belz,
Fabienne Mackay,
Stephane Richard,
David Tarlinton

Affiliations

Simona Infantino: Walter and Eliza Hall Institute of Medical Research
Amanda Light: Walter and Eliza Hall Institute of Medical Research
Kristy O’Donnell: Walter and Eliza Hall Institute of Medical Research
Vanessa Bryant: Walter and Eliza Hall Institute of Medical Research
Danielle T. Avery: Immunology Division, Garvan Institute of Medical Research
Michael Elliott: Sydney Medical School, University of Sydney
Stuart G. Tangye: Immunology Division, Garvan Institute of Medical Research
Gabrielle Belz: Walter and Eliza Hall Institute of Medical Research
Fabienne Mackay: Department of Microbiology and Immunology, University of Melbourne
Stephane Richard: Lady Davis Institute for Medical Research, McGill University
David Tarlinton: Walter and Eliza Hall Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-017-01009-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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