Relationship of galectin-3 and brain natriouretic peptide levels with the type of left ventricle remodeling in patients with coronary heart disease after coronary arto bypass graft

Abstract

Relevance. Today, the search for biomarkers capable of predicting the duration of rehabilitation after CABG in patients with CAD is relevant. Aim. To assess the features of the left cardiac chamber remodeling with regard to the levels of NT-proBNP and galectin-3 in patients with CAD after CABG. Methods. The study involved 100 males with CAD, who underwent CABG. Group 1 included 58 patients, who started working within 4 months after intervention. Group 2 included 42 patients, whose rehabilitation period exceeded 4 months. Echocardiography was performed in all patients, the levels of galectin-3, NT-proBNP were determined 1 and 4 months after CABG. Results. Assessment of the LV remodeling variants 1 month after CABG showed that hypertrophic variants of remodeling prevailed in group 2, while in group 1 these were reported less than in half of the cases. The increase in the rate of unfavorable LV remodeling variants by month 4 was observed in group 2. Initial comparison showed that the galectin-3 and NT-proBNP levels in group 2 were significantly higher than that in group 1 (17.95 (17.2÷19.3) vs. 11.35 (8.2÷14.7) ng/mL, p<0.01 and 372 (320.3÷445) vs. 287.5 (232.5÷391.3) pg/mL, p<0.01, respectively). These indicators showed no upward trend by month 4 in group 1, while in group 2 a significant increase in the levels of galectin-3 and NT-proBNP was reported. Positive correlations of varying strength between the galectin-l levels and the LV remodeling types, NT-proBNP levels and the LV remodeling types were revealed in both groups. Discussion. The association of high marker (galectin-3 and NT-proBNP) levels with unfavorable LV remodeling types in the group with prolonged recovery was demonstrated during the study. The studied markers are proxy indicators for the processes underlying maladaptive morphofunctional remodeling of myocardium resulting in myocardial dysfunction, which can be the cause of prolonged recovery after the CABG surgery. Conclusions. The correlations revealed can have clinical significance for early detection of LV remodeling in patients with CAD associated with prolonged recovery after CABG.

Keywords

• galectin-3
• brain natriuretic peptide
• coronary artery bypass grafting
• remodeling