Frontiers in Oncology (Apr 2024)

Implementation of a roadmap for the comprehensive diagnosis, follow-up, and research of childhood leukemias in vulnerable regions of Mexico: results from the PRONAII Strategy

  • Juan Carlos Núñez-Enríquez,
  • Rubí Romo-Rodríguez,
  • Rubí Romo-Rodríguez,
  • Pedro Gaspar-Mendoza,
  • Pedro Gaspar-Mendoza,
  • Gabriela Zamora-Herrera,
  • Gabriela Zamora-Herrera,
  • Lizeth Torres-Pineda,
  • Lizeth Torres-Pineda,
  • Jiovanni Amador-Cardoso,
  • Jiovanni Amador-Cardoso,
  • Jebea A. López-Blanco,
  • Laura Alfaro-Hernández,
  • Laura Alfaro-Hernández,
  • Lucero López-García,
  • Arely Rosas-Cruz,
  • Dulce Rosario Alberto-Aguilar,
  • Dulce Rosario Alberto-Aguilar,
  • César Omar Trejo-Pichardo,
  • Dalia Ramírez-Ramírez,
  • Astin Cruz-Maza,
  • Astin Cruz-Maza,
  • Janet Flores-Lujano,
  • Nuria Luna-Silva,
  • Angélica Martínez-Martell,
  • Karina Martínez-Jose,
  • Anabel Ramírez-Ramírez,
  • Juan Carlos Solis-Poblano,
  • Patricia Zagoya-Martínez,
  • Vanessa Terán-Cerqueda,
  • Andrea Huerta-Moreno,
  • Álvaro Montiel-Jarquín,
  • Miguel Garrido-Hernández,
  • Raquel Hernández-Ramos,
  • Daniela Olvera-Caraza,
  • Cynthia Shanat Cruz-Medina,
  • Cynthia Shanat Cruz-Medina,
  • Enoch Alvarez-Rodríguez,
  • Enoch Alvarez-Rodríguez,
  • Lénica Anahí Chávez-Aguilar,
  • Wilfrido Herrera-Olivares,
  • Wilfrido Herrera-Olivares,
  • Brianda García-Hidalgo,
  • Lena Sarahí Cano-Cuapio,
  • Claudia Guevara-Espejel,
  • Gerardo Juárez-Avendaño,
  • Juan Carlos Balandrán,
  • Ma. del Rocío Baños-Lara,
  • Mariana Cárdenas-González,
  • Elena R. Álvarez-Buylla,
  • Sonia Mayra Pérez-Tapia,
  • Sonia Mayra Pérez-Tapia,
  • Sonia Mayra Pérez-Tapia,
  • Diana Casique-Aguirre,
  • Diana Casique-Aguirre,
  • Rosana Pelayo,
  • Rosana Pelayo

DOI
https://doi.org/10.3389/fonc.2024.1304690
Journal volume & issue
Vol. 14

Abstract

Read online

The main objective of the National Project for Research and Incidence of Childhood Leukemias is to reduce early mortality rates for these neoplasms in the vulnerable regions of Mexico. This project was conducted in the states of Oaxaca, Puebla, and Tlaxcala. A key strategy of the project is the implementation of an effective roadmap to ensure that leukemia patients are the target of maximum benefit of interdisciplinary collaboration between researchers, clinicians, surveyors, and laboratories. This strategy guarantees the comprehensive management of diagnosis and follow-up samples of pediatric patients with leukemia, centralizing, managing, and analyzing the information collected. Additionally, it allows for a precise diagnosis and monitoring of the disease through immunophenotype and measurable residual disease (MRD) studies, enhancing research and supporting informed clinical decisions for the first time in these regions through a population-based study. This initiative has significantly improved the diagnostic capacity of leukemia in girls, boys, and adolescents in the regions of Oaxaca, Puebla, and Tlaxcala, providing comprehensive, high-quality care with full coverage in the region. Likewise, it has strengthened collaboration between health institutions, researchers, and professionals in the sector, which contributes to reducing the impact of the disease on the community.

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