Overactive bladder in women with stress urinary incontinence

Abstract

The estimation of the role of a functional component in the development of urination disorders in women with stress urination incontinence (SUI) concurrent with imperative urge urination incontinence that is a manifestation of overactive bladder (OAB) has become particularly relevant in recent years. Urodynamic study reveals the signs of SUI concurrent with detrusor overactivity. The purpose of the investigation was to improve the results of OAB treatment in women with SUI and to study a relationship between the clinical and urodynamic manifestations of the disease. Forty treated women with OAB and SUI were examined. All the patients received combination medical therapy: an Mcholinolytic (solifenacin 10 mg once daily in the morning), picamilonum 5 mg thrice daily, and exercises to strengthen pelvic floor muscles. The treatment lasted 3 months. After the treatment, urinary output and maximal urine flow rate changed, by reaching the normal values in patients with rapid and obstructive urination. Cystometric capacity was increased; involuntary detrusor contractions (spontaneous or provoked) became fewer during bladder filling or they were absent at all. Our investigation has determined that the combination medical treatment whose basis is the M-cholinolytic drug solifenacin is effective in treating OAB in women with SUI. Thus, the combination medical treatment considerably reduces the degree of clinical symptoms of OAB in women with SUI and it is the first stage in the treatment of patients with mixed urinary incontinence. According to the results of the performed treatment and examination, the clinical effect was observed in 18 (72 %) patients.

Keywords

• overactive bladder
• stress urinary incontinence
• urodynamics
• M-cholinolytic