Nature Communications (Nov 2016)
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes
- Raphael Reuten,
- Trushar R. Patel,
- Matthew McDougall,
- Nicolas Rama,
- Denise Nikodemus,
- Benjamin Gibert,
- Jean-Guy Delcros,
- Carina Prein,
- Markus Meier,
- Stéphanie Metzger,
- Zhigang Zhou,
- Jennifer Kaltenberg,
- Karen K. McKee,
- Tobias Bald,
- Thomas Tüting,
- Paola Zigrino,
- Valentin Djonov,
- Wilhelm Bloch,
- Hauke Clausen-Schaumann,
- Ernst Poschl,
- Peter D. Yurchenco,
- Martin Ehrbar,
- Patrick Mehlen,
- Jörg Stetefeld,
- Manuel Koch
Affiliations
- Raphael Reuten
- Institute for Dental Research and Oral Musculoskeletal Biology, Medical Faculty, University of Cologne
- Trushar R. Patel
- Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge
- Matthew McDougall
- Department of Chemistry, University of Manitoba
- Nicolas Rama
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
- Denise Nikodemus
- Institute for Dental Research and Oral Musculoskeletal Biology, Medical Faculty, University of Cologne
- Benjamin Gibert
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
- Jean-Guy Delcros
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
- Carina Prein
- Center for Applied Tissue Engineering and Regenerative Medicine–CANTER, Munich University of Applied Sciences
- Markus Meier
- Department of Chemistry, University of Manitoba
- Stéphanie Metzger
- Department of Obstetrics, Laboratory for Cell and Tissue Engineering, University Hospital Zurich
- Zhigang Zhou
- School of Biological Sciences, University of East Anglia, Norwich Research Park
- Jennifer Kaltenberg
- Institute for Dental Research and Oral Musculoskeletal Biology, Medical Faculty, University of Cologne
- Karen K. McKee
- Department of Pathology, Robert Wood Johnson Medical School
- Tobias Bald
- Department of Dermatology, University Hospital Magdeburg
- Thomas Tüting
- Department of Dermatology, University Hospital Magdeburg
- Paola Zigrino
- Department of Dermatology and Venerology, University of Cologne
- Valentin Djonov
- Institute of Anatomy, University of Bern
- Wilhelm Bloch
- Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne
- Hauke Clausen-Schaumann
- Center for Applied Tissue Engineering and Regenerative Medicine–CANTER, Munich University of Applied Sciences
- Ernst Poschl
- School of Biological Sciences, University of East Anglia, Norwich Research Park
- Peter D. Yurchenco
- Department of Pathology, Robert Wood Johnson Medical School
- Martin Ehrbar
- Department of Obstetrics, Laboratory for Cell and Tissue Engineering, University Hospital Zurich
- Patrick Mehlen
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
- Jörg Stetefeld
- Department of Chemistry, University of Manitoba
- Manuel Koch
- Institute for Dental Research and Oral Musculoskeletal Biology, Medical Faculty, University of Cologne
- DOI
- https://doi.org/10.1038/ncomms13515
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modulate laminin-laminin interactions.
