Is there a connection between iron exchange and COVID-19?

Abstract

The review analyzes possible epidemiological and molecular mechanisms responsible for hyperinflammation in patients with the severe course of COVID-19.Results: it highlights the similarities between this condition and hyperferritinemic syndrome which allows considering pathogenesis of COVID-19 with the direct involvement of iron metabolism. In the case of COVID-19 infection of moderate severity and especially in its severe forms, it is indicated to use of iron chelators and other methods of free iron elimination.

Keywords

• covid-19
• cytokine storm
• iron metabolism
• hyperferritinemia
• iron chelators