Effects of multi-mode physical stimulation on APP/PS1 Alzheimer's disease model mice

Shupeng Liu; Shuyang Li; Yudan Xia; Heng Zhang; Jing Tian; Chunlei Shan; Fufei Pang; Ying Wang; Yana Shang; Na Chen

Heliyon (Dec 2022)

Effects of multi-mode physical stimulation on APP/PS1 Alzheimer's disease model mice

Shupeng Liu,
Shuyang Li,
Yudan Xia,
Heng Zhang,
Jing Tian,
Chunlei Shan,
Fufei Pang,
Ying Wang,
Yana Shang,
Na Chen

Affiliations

Shupeng Liu: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, 200444, China; Corresponding author.
Shuyang Li: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, 200444, China
Yudan Xia: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, 200444, China
Heng Zhang: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, 200444, China
Jing Tian: School of Electron and Computer, Southeast University Chengxian College, Nanjing, 210088, China; Corresponding author.
Chunlei Shan: School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
Fufei Pang: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, 200444, China
Ying Wang: School of Public Health, Fudan University, Shanghai, 200032, China
Yana Shang: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, 200444, China
Na Chen: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, 200444, China; Corresponding author.

Journal volume & issue: Vol. 8, no. 12
p. e12366

Abstract

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Some researchers and clinics have reported that non-drug treatments for Alzheimer disease (AD) such as electrical stimulation, light stimulation, music stimulation, laser stimulation, and transcranial magnetic stimulation may have beneficial treatment effects. Following these findings, in this study, we performed multimodel physical stimulation on APP/PS1 mice using visible light, music with a γ rhythm, and an infrared laser. And the effects of physical stimulation on APP/PS1 mice were evaluated by behavioral analysis, the content of amyloid (Aβ40 and Aβ42), and NISSL staining of hippocampal tissue slices. The results of subsequent behavioral and tissue analyses showed that the multi-model physical stimulations could relieve APP/PS1 mice's dementia symptoms, such as the behavior ability, the content of Aβ40 and Aβ42 in the hippocampal tissue suspension, and Nissl staining for hippocampal tissue analyses.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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