Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division

Zelin Shan; Yuting Tu; Ying Yang; Ziheng Liu; Menglong Zeng; Huisha Xu; Jiafu Long; Mingjie Zhang; Yu Cai; Wenyu Wen

doi:10.1038/s41467-018-03077-3

Nature Communications (Feb 2018)

Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division

Zelin Shan,
Yuting Tu,
Ying Yang,
Ziheng Liu,
Menglong Zeng,
Huisha Xu,
Jiafu Long,
Mingjie Zhang,
Yu Cai,
Wenyu Wen

Affiliations

Zelin Shan: Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
Yuting Tu: Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
Ying Yang: Temasek Life Sciences Laboratory, Department of Biological Sciences, National University of Singapore
Ziheng Liu: Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
Menglong Zeng: Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology
Huisha Xu: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University
Jiafu Long: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University
Mingjie Zhang: Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology
Yu Cai: Temasek Life Sciences Laboratory, Department of Biological Sciences, National University of Singapore
Wenyu Wen: Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University

DOI: https://doi.org/10.1038/s41467-018-03077-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Polarized localization of Numb and Pon in Drosophila neuroblasts (NBs) enables their unequal segregation during asymmetric cell divisions. Here, the authors demonstrate liquid-liquid phase separation of Pon and Numb in NBs mediated by multivalent intermolecular interactions is required for their basal condensation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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