Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture

Emma R. Stewart; Robert M. L. Turner; Katherine Newling; Rebeca Ridings-Figueroa; Victoria Scott; Peter D. Ashton; Justin F. X. Ainscough; Dawn Coverley

doi:10.1038/s41467-018-08072-2

Nature Communications (Jan 2019)

Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture

Emma R. Stewart,
Robert M. L. Turner,
Katherine Newling,
Rebeca Ridings-Figueroa,
Victoria Scott,
Peter D. Ashton,
Justin F. X. Ainscough,
Dawn Coverley

Affiliations

Emma R. Stewart: Department of Biology, University of York
Robert M. L. Turner: Department of Biology, University of York
Katherine Newling: York Bioscience Technology Facility, University of York
Rebeca Ridings-Figueroa: Department of Biology, University of York
Victoria Scott: Department of Biology, University of York
Peter D. Ashton: York Bioscience Technology Facility, University of York
Justin F. X. Ainscough: Department of Biology, University of York
Dawn Coverley: Department of Biology, University of York

DOI: https://doi.org/10.1038/s41467-018-08072-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The inactive X chromosome (Xi) is a model for establishment and maintenance of repressed chromatin and the function of polycomb repressive complexes. Here the authors show that Xi transiently relocates from the nuclear periphery during replication in a CIZ1-dependent manner, which plays a role in maintaining PRC-mediated repressed chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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