The CYP17A1 rs743572 Gene Polymorphism and Risk of Development and Clinical Features of Acne Vulgaris in the Uzbek Population

Abstract

The purpose of this study was to analyze the association between the CYP17A1 rs743572 SNP and the development and clinical course of Acne vulgaris (AV) in the Uzbek population. The study included 165 AV patients aged from 18 to 30 years (Group AV). All patients were divided into 3 subgroups in accordance with the severity of the disease. SAV1 included 59(35.8%) patients with a mild degree of AV, SAV2 included 64(38.8%) patients with a moderate degree of AV, and SAV3 included 42(25.4%) patients with a severe degree of AV. The control group (CG) consisted of 97 healthy volunteers without a burdened dermatological history. Our study revealed a significant association of the CYP17A1 rs743572 SNP with the risk of AV development in the Uzbek population. Our results showed that the presence of the A2 allele and A2/A2 genotype of the CYP17A1 rs743572 SNP might be a risk factor for AV in Uzbek ethnicity. It is obvious that the A1/A1 genotype of the CYP17A1 rs743572 SNP can have a protective effect not only in the formation of AV, but also in the severity of the disease. The functionally unfavorable A1/A2 genotype of the CYP17A1 rs743572 SNP is more characteristic of patients with a moderate degree of AV, and the homozygote minor allele genotype A2/A2 is more characteristic of patients with a severe degree of AV.

Keywords

• acne vulgaris
• single nucleotide polymorphism
• CYP17A1 gene
• rs743572