Nature Communications (Sep 2022)
Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
- Mikhail A. Hameedi,
- Erica T. Prates,
- Michael R. Garvin,
- Irimpan I. Mathews,
- B. Kirtley Amos,
- Omar Demerdash,
- Mark Bechthold,
- Mamta Iyer,
- Simin Rahighi,
- Daniel W. Kneller,
- Andrey Kovalevsky,
- Stephan Irle,
- Van-Quan Vuong,
- Julie C. Mitchell,
- Audrey Labbe,
- Stephanie Galanie,
- Soichi Wakatsuki,
- Daniel Jacobson
Affiliations
- Mikhail A. Hameedi
- SLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Structural Molecular Biology
- Erica T. Prates
- National Virtual Biotechnology Laboratory, US Department of Energy
- Michael R. Garvin
- National Virtual Biotechnology Laboratory, US Department of Energy
- Irimpan I. Mathews
- SLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Structural Molecular Biology
- B. Kirtley Amos
- Department of Horticulture, University of Kentucky
- Omar Demerdash
- National Virtual Biotechnology Laboratory, US Department of Energy
- Mark Bechthold
- Department of Structural Biology, Stanford University
- Mamta Iyer
- Chapman University School of Pharmacy
- Simin Rahighi
- Chapman University School of Pharmacy
- Daniel W. Kneller
- National Virtual Biotechnology Laboratory, US Department of Energy
- Andrey Kovalevsky
- National Virtual Biotechnology Laboratory, US Department of Energy
- Stephan Irle
- Computational Sciences and Engineering Division, Oak Ridge National Laboratory
- Van-Quan Vuong
- The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee Knoxville
- Julie C. Mitchell
- National Virtual Biotechnology Laboratory, US Department of Energy
- Audrey Labbe
- National Virtual Biotechnology Laboratory, US Department of Energy
- Stephanie Galanie
- National Virtual Biotechnology Laboratory, US Department of Energy
- Soichi Wakatsuki
- SLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Structural Molecular Biology
- Daniel Jacobson
- National Virtual Biotechnology Laboratory, US Department of Energy
- DOI
- https://doi.org/10.1038/s41467-022-32922-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The authors report crystallographic and computational studies that detail how SARS-CoV-2 3CLpro cleaves the host NF-κB Essential Modulator in addition to its canonical viral substrates. The association with the high fitness of SARS-CoV-2 in humans is discussed.
