Frontiers in Endocrinology (Mar 2022)

A Cohort Study on the Immunogenicity and Safety of the Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV) in Patients With Breast Cancer; Does Trastuzumab Interfere With the Outcome?

  • Maryam Joudi,
  • Maryam Moradi Binabaj,
  • Pejman Porouhan,
  • Babak PeyroShabany,
  • Mohsen Tabasi,
  • Danial Fazilat-Panah,
  • Mahtab Khajeh,
  • Arezoo Mehrabian,
  • Mansoureh Dehghani,
  • James S. Welsh,
  • Batol Keykhosravi,
  • Azam Akbari Yazdi,
  • Mona Ariamanesh,
  • Ahmad Ghasemi,
  • Gordon Ferns,
  • Seyed Alireza Javadinia

DOI
https://doi.org/10.3389/fendo.2022.798975
Journal volume & issue
Vol. 13

Abstract

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AimTo determine the efficacy and safety of inactivated SARS-CoV-2 vaccine (BBIBP-CorV) in patients with breast cancer.MethodsIn this multi- institutional cohort study, a total of 160 breast cancer patients (mean age of 50.01 ± 11.5 years old) were assessed for the SARS-CoV-2 Anti-Spike IgG and SARS-CoV2 Anti RBD IgG by ELISA after two doses of 0.5 mL inactivated, COVID-19 vaccine (BBIBP-CorV). All patients were followed up for three months for clinical COVID-19 infection based on either PCR results or imaging findings. Common Terminology Criteria for Adverse Events were used to assess the side effects.ResultsThe presence of SARS-CoV-2 anti-spike IgG, SARS-CoV2 anti-RBD IgG, or either of these antibodies was 85.7%, 87.4%, and 93.3%. The prevalence of COVID-19 infection after vaccination was 0.7%, 0% and 0% for the first, second and third months of the follow-up period. The most common local and systemic side-effects were injection site pain and fever which were presented in 22.3% and 24.3% of patients, respectively.DiscussionThe inactivated SARS-CoV-2 vaccine (BBIBP-CorV) is a tolerable and effective method to prevent COVID-19.

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