Evaluation of the ALBI, MELD, MELD-Na, MELD 3.0 score in patients with hepatocellular carcinoma treated with Yttrium-90 (90y)

Abstract

Introduction and Objectives: Hepatocellular carcinoma (HCC) occupies the third cause of mortality worldwide. 10% of patients receive curative therapy. There are loco-regional therapies to improve patient survival such as (TACE) and radioembolization with Yttrium-90. There are prognostic scales, such as ALBI, MELD, MELD-Na, MELD 3.0, to identify those who will respond better to treatment.To evaluate the potential of the ALBI, MELD, MELD-Na, MELD 3.0 index as a predictor of mortality in patients who received treatment with Yttrium-90 Materials and Patients: Patients with cirrhosis and HCC who were candidates for radiation embolization with Yttrium-90 were evaluated. The following scores ALBI, MELD, MELD-Na, MELD 3.0 were assessed before and after therapy. Results: There were 7 patients, age 70±11.3 years, 60% women, all BCLC B and Child Pugh B, etiology of CH was 3 patients due to alcohol-associated liver disease, 2 patients due to MASLD and 2 cryptogenic, 4 patients had 2 sessions and 3 patients 1 session, complete response in 3 patients and 5 progressed. 3 patients died. The variables of leukocytes, hemoglobin, platelets, PT, INR, BT, AST, ALT, albumin, ALBI, MELD, MELD 3.0, MELD-Na, Child Pugh were compared without obtaining statistical significance (Table 1). The survival of the patients was 14.6 months. There were no complications or adverse effects with the Yttrium-90 treatment. Conclusions: ALBI, MELD, MELD 3.0, MELD-Na score do not predict mortality in patients treated with Yttrium-90. A study with a larger number of patients is needed to correlate and obtain more significant results