Synthesis and Antioxidant Activities of [5-fluoro N, N'-bis (salicylidene) ethylenediamine] and [3, 5-fluoro N, N'-bis (salicylidene) ethylenediamine] Manganese (III) Complexes

Abstract

Antioxidants act as free radical scavengers in the oxidation processes. Thus, they will certainly play diverse roles in the biological systems and the therapy of a wide variety of diseases. Regarding this fact, in the present study, we synthesized two new salen ligand compounds by the condensation of ethylendiamine and salicylaldehyde derivatives in excellent yields.The structures of these ligands were confirmed by IR, 1H NMR and mass spectroscopy techniques. Furthermore, we evaluated the relative dismutase, catalase and peroxidase activities of the newly synthesized complexes named as EUKs 131, 132, 141 and 142 relative to EUKs 108 and 8, as the reference compounds. The results demonstrated that all Mn-salen complexes (EUKs) illustrated significant dismutase, catalase and peroxidase activities. EUKs 131 and 8 showed the most catalase and peroxidase activities while their dismutase activities were almost the same as the other compounds. In addition, our data indicated that the biological activities of the EUKs are modulated by manganese element as well as the types and the positions of substituents on the ligand.

Keywords

• mn-salen complexes
• synthesis
• antioxidant
• dismutase
• catalase
• peroxidase