Application of an analytical framework for multivariate mediation analysis of environmental data

Max T. Aung; Yanyi Song; Kelly K. Ferguson; David E. Cantonwine; Lixia Zeng; Thomas F. McElrath; Subramaniam Pennathur; John D. Meeker; Bhramar Mukherjee

doi:10.1038/s41467-020-19335-2

Nature Communications (Nov 2020)

Application of an analytical framework for multivariate mediation analysis of environmental data

Max T. Aung,
Yanyi Song,
Kelly K. Ferguson,
David E. Cantonwine,
Lixia Zeng,
Thomas F. McElrath,
Subramaniam Pennathur,
John D. Meeker,
Bhramar Mukherjee

Affiliations

Max T. Aung: Department of Biostatistics, University of Michigan School of Public Health
Yanyi Song: Department of Biostatistics, University of Michigan School of Public Health
Kelly K. Ferguson: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park
David E. Cantonwine: Division of Maternal and Fetal Medicine, Brigham and Women’s Hospital, Harvard Medical School
Lixia Zeng: Department of Internal Medicine-Nephrology, University of Michigan
Thomas F. McElrath: Division of Maternal and Fetal Medicine, Brigham and Women’s Hospital, Harvard Medical School
Subramaniam Pennathur: Department of Internal Medicine-Nephrology, University of Michigan
John D. Meeker: Department of Environmental Health Sciences, University of Michigan School of Public Health
Bhramar Mukherjee: Department of Biostatistics, University of Michigan School of Public Health

DOI: https://doi.org/10.1038/s41467-020-19335-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Diverse toxicological mechanisms may mediate the impact of environmental toxicants on pregnancy outcomes. In this study the authors introduce an analytical framework for multivariate mediation analysis to identify mediation pathways in the relationship between environmental toxicants and gestational age at delivery.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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