Nature Communications (Nov 2019)

Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development

  • Ryo Seishima,
  • Carly Leung,
  • Swathi Yada,
  • Katzrin Bte Ahmed Murad,
  • Liang Thing Tan,
  • Amin Hajamohideen,
  • Si Hui Tan,
  • Hideki Itoh,
  • Kazuhiro Murakami,
  • Yoshihiro Ishida,
  • Satoshi Nakamizo,
  • Yusuke Yoshikawa,
  • Esther Wong,
  • Nick Barker

DOI
https://doi.org/10.1038/s41467-019-13363-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

Read online

Uterine gland development is essential for successful embryo implantation, decidua formation and placental development. Here the authors demonstrate that neonatal Wnt-dependent Lgr5 expressing stem/progenitor cells at the tips of developing glands are indispensable for uterine gland development.