L-proline catalyzed efficient and clean synthesis of polysubstituted benzenes in the ionic liquid [bmim]PF6

Abstract

A clean and efficient synthesis of polysubstituted benzenes has been developed via sequential vinylogous Michael addition and nucleophilic cyclization reactions of arylethylidenemalonodinitriles with arylidenemalo-nodinitriles in ionic liquid [bmim]PF6 catalyzed by L-proline.

Keywords

• polysubstituted benzenes
• organocatalysis
• ionic liquids
• green chemistry