Nature Communications (Feb 2022)
TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy
Abstract
The immunopathology of Duchenne Muscular Dystrophy includes a disturbed balance of pro and anti-inflammatory macrophages. Here the authors implicate trained innate immunity in a murine model of the disease, and reveal TLR4 as a key regulator of this process.