Frontiers in Endocrinology (Dec 2021)
Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)
- Ines Foessl,
- J. H. Duncan Bassett,
- Åshild Bjørnerem,
- Åshild Bjørnerem,
- Björn Busse,
- Ângelo Calado,
- Pascale Chavassieux,
- Maria Christou,
- Eleni Douni,
- Eleni Douni,
- Imke A. K. Fiedler,
- João Eurico Fonseca,
- João Eurico Fonseca,
- Eva Hassler,
- Wolfgang Högler,
- Erika Kague,
- David Karasik,
- Patricia Khashayar,
- Bente L. Langdahl,
- Victoria D. Leitch,
- Philippe Lopes,
- Georgios Markozannes,
- Fiona E. A. McGuigan,
- Carolina Medina-Gomez,
- Evangelia Ntzani,
- Evangelia Ntzani,
- Ling Oei,
- Claes Ohlsson,
- Claes Ohlsson,
- Pawel Szulc,
- Jonathan H. Tobias,
- Jonathan H. Tobias,
- Katerina Trajanoska,
- Şansın Tuzun,
- Amina Valjevac,
- Bert van Rietbergen,
- Graham R. Williams,
- Tatjana Zekic,
- Fernando Rivadeneira,
- Barbara Obermayer-Pietsch
Affiliations
- Ines Foessl
- Department of Internal Medicine, Division of Endocrinology and Diabetology, Endocrine Lab Platform, Medical University of Graz, Graz, Austria
- J. H. Duncan Bassett
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom
- Åshild Bjørnerem
- Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway
- Åshild Bjørnerem
- Norwegian Research Centre for Women’s Health, Oslo University Hospital, Oslo, Norway
- Björn Busse
- Department of Osteology and Biomechanics, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
- Ângelo Calado
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisboa, Portugal
- Pascale Chavassieux
- INSERM UMR 1033, University of Lyon, Lyon, France
- Maria Christou
- Department of Hygiene and Epidemiology, Medical School, University of Ioannina, Ioannina, Greece
- Eleni Douni
- Institute for Bioinnovation, Biomedical Sciences Research Center “Alexander Fleming”, Vari, Greece
- Eleni Douni
- 0Department of Biotechnology, Agricultural University of Athens, Athens, Greece
- Imke A. K. Fiedler
- Department of Osteology and Biomechanics, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
- João Eurico Fonseca
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisboa, Portugal
- João Eurico Fonseca
- 1Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisbon Academic Medical Centre, Lisbon, Portugal
- Eva Hassler
- 2Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University Graz, Graz, Austria
- Wolfgang Högler
- 3Department of Paediatrics and Adolescent Medicine, Johannes Kepler University Linz, Linz, Austria
- Erika Kague
- 4The School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences, University of Bristol, Bristol, United Kingdom
- David Karasik
- 5Azrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel
- Patricia Khashayar
- 6Center for Microsystems Technology, Imec and Ghent University, Ghent, Belgium
- Bente L. Langdahl
- 7Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
- Victoria D. Leitch
- 8Innovative Manufacturing Cooperative Research Centre, Royal Melbourne Institute of Technology, School of Engineering, Carlton, VIC, Australia
- Philippe Lopes
- 0Department of Clinical Sciences, Lund University, Malmö, Sweden
- Georgios Markozannes
- Department of Hygiene and Epidemiology, Medical School, University of Ioannina, Ioannina, Greece
- Fiona E. A. McGuigan
- 0Department of Clinical Sciences, Lund University, Malmö, Sweden
- Carolina Medina-Gomez
- 1Department of Internal Medicine, Erasmus MC Rotterdam, Rotterdam, Netherlands
- Evangelia Ntzani
- Department of Hygiene and Epidemiology, Medical School, University of Ioannina, Ioannina, Greece
- Evangelia Ntzani
- 2Department of Health Services, Policy and Practice, Center for Research Synthesis in Health, School of Public Health, Brown University, Providence, RI, United States
- Ling Oei
- 3Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
- Claes Ohlsson
- 3Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
- Claes Ohlsson
- 4Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden
- Pawel Szulc
- INSERM UMR 1033, University of Lyon, Lyon, France
- Jonathan H. Tobias
- 5Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
- Jonathan H. Tobias
- 6MRC Integrative Epidemiology Unit, Bristol Medical School, Bristol, University of Bristol, Bristol, United Kingdom
- Katerina Trajanoska
- 1Department of Internal Medicine, Erasmus MC Rotterdam, Rotterdam, Netherlands
- Şansın Tuzun
- 7Physical Medicine & Rehabilitation Department, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey
- Amina Valjevac
- 8Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
- Bert van Rietbergen
- 9Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
- Graham R. Williams
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom
- Tatjana Zekic
- 0Department of Rheumatology and Clinical Immunology, Faculty of Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia
- Fernando Rivadeneira
- 1Department of Internal Medicine, Erasmus MC Rotterdam, Rotterdam, Netherlands
- Barbara Obermayer-Pietsch
- Department of Internal Medicine, Division of Endocrinology and Diabetology, Endocrine Lab Platform, Medical University of Graz, Graz, Austria
- DOI
- https://doi.org/10.3389/fendo.2021.720728
- Journal volume & issue
-
Vol. 12
Abstract
A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.
Keywords
