PLoS ONE (Jan 2021)

Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.

  • Katsunori Matsueda,
  • Hiromitsu Kanzaki,
  • Ryuta Takenaka,
  • Masahiro Nakagawa,
  • Kazuhiro Matsueda,
  • Masaya Iwamuro,
  • Seiji Kawano,
  • Yoshiro Kawahara,
  • Tomohiro Toji,
  • Takehiro Tanaka,
  • Takahito Yagi,
  • Toshiyoshi Fujiwara,
  • Hiroyuki Okada

DOI
https://doi.org/10.1371/journal.pone.0256797
Journal volume & issue
Vol. 16, no. 8
p. e0256797

Abstract

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ObjectiveThe rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).MaterialsWe retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.ResultsAmong the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).ConclusionsSM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca.