Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors

Bárbara Coimbra; Carina Soares-Cunha; Nivaldo A P Vasconcelos; Ana Verónica Domingues; Sónia Borges; Nuno Sousa; Ana João Rodrigues

doi:10.1038/s41467-019-11557-3

Nature Communications (Sep 2019)

Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors

Bárbara Coimbra,
Carina Soares-Cunha,
Nivaldo A P Vasconcelos,
Ana Verónica Domingues,
Sónia Borges,
Nuno Sousa,
Ana João Rodrigues

Affiliations

Bárbara Coimbra: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
Carina Soares-Cunha: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
Nivaldo A P Vasconcelos: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
Ana Verónica Domingues: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
Sónia Borges: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
Nuno Sousa: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
Ana João Rodrigues: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho

DOI: https://doi.org/10.1038/s41467-019-11557-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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The laterodorsal tegmental nucleus (LDT) is known to influence reward processing through its projections to the VTA. Here, the authors report that the cholinergic projections from the LDT to the nucleus accumbens play an important role in motivation and positive reinforcement behaviors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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