Nature Communications (Aug 2022)
MYC sensitises cells to apoptosis by driving energetic demand
- Joy Edwards-Hicks,
- Huizhong Su,
- Maurizio Mangolini,
- Kubra K. Yoneten,
- Jimi Wills,
- Giovanny Rodriguez-Blanco,
- Christine Young,
- Kevin Cho,
- Heather Barker,
- Morwenna Muir,
- Ania Naila Guerrieri,
- Xue-Feng Li,
- Rachel White,
- Piotr Manasterski,
- Elena Mandrou,
- Karen Wills,
- Jingyu Chen,
- Emily Abraham,
- Kianoosh Sateri,
- Bin-Zhi Qian,
- Peter Bankhead,
- Mark Arends,
- Noor Gammoh,
- Alex von Kriegsheim,
- Gary J. Patti,
- Andrew H. Sims,
- Juan Carlos Acosta,
- Valerie Brunton,
- Kamil R. Kranc,
- Maria Christophorou,
- Erika L. Pearce,
- Ingo Ringshausen,
- Andrew J. Finch
Affiliations
- Joy Edwards-Hicks
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Huizhong Su
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Maurizio Mangolini
- Wellcome Trust/MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Kubra K. Yoneten
- Barts Cancer Institute, Queen Mary University of London
- Jimi Wills
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Giovanny Rodriguez-Blanco
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Christine Young
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Kevin Cho
- Department of Chemistry and Medicine, Washington University School of Medicine
- Heather Barker
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Morwenna Muir
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Ania Naila Guerrieri
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Xue-Feng Li
- MRC University of Edinburgh Centre for Reproductive Health, University of Edinburgh
- Rachel White
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Piotr Manasterski
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Elena Mandrou
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Karen Wills
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Jingyu Chen
- Wellcome Trust/MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Emily Abraham
- Barts Cancer Institute, Queen Mary University of London
- Kianoosh Sateri
- Barts Cancer Institute, Queen Mary University of London
- Bin-Zhi Qian
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Peter Bankhead
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Mark Arends
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Noor Gammoh
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Alex von Kriegsheim
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Gary J. Patti
- Department of Chemistry and Medicine, Washington University School of Medicine
- Andrew H. Sims
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Juan Carlos Acosta
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Valerie Brunton
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Kamil R. Kranc
- Barts Cancer Institute, Queen Mary University of London
- Maria Christophorou
- Wellcome Trust/MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Erika L. Pearce
- Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
- Ingo Ringshausen
- Wellcome Trust/MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Andrew J. Finch
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-022-32368-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
MYC activation can sensitise cells to apoptosis upon glutamine withdrawal. Here the authors show that MYC activation enhances global transcription and translation that creates a metabolic demand, while glutamine limitation causes a metabolic demand and supply imbalance through loss of TCA energetics and thus, sensitises cells to apoptosis.
