Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes

• Vedagopuram Sreekanth,
• Qingxuan Zhou,
• Praveen Kokkonda,
• Heysol C. Bermudez-Cabrera,
• Donghyun Lim,
• Benjamin K. Law,
• Benjamin R. Holmes,
• Santosh K. Chaudhary,
• Rajaiah Pergu,
• Brittany S. Leger,
• James A. Walker,
• David K. Gifford,
• Richard I. Sherwood,
• Amit Choudhary

Affiliations

Vedagopuram Sreekanth

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States

Qingxuan Zhou

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States

Praveen Kokkonda

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States

Heysol C. Bermudez-Cabrera

Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States

Donghyun Lim

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States

Benjamin K. Law

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States

Benjamin R. Holmes

McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts, United States

Santosh K. Chaudhary

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States

Rajaiah Pergu

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States

Brittany S. Leger

Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States

James A. Walker

Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States

David K. Gifford

McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts, United States

Richard I. Sherwood

Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States

Amit Choudhary

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States