Nature Communications (Nov 2021)

Dissection of the amyloid formation pathway in AL amyloidosis

  • Pamina Kazman,
  • Ramona M. Absmeier,
  • Harald Engelhardt,
  • Johannes Buchner

DOI
https://doi.org/10.1038/s41467-021-26845-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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AL amyloidosis is caused by the accumulation of overproduced light chain (LC) fragments as fibrils in patient organs and it is the most prevalent systemic amyloidosis. Here, the authors combine biochemical and biophysical experiments to characterise the lag phase of a patient-derived truncated LC and they identify structural transitions that precede fibril formation.