Nature Communications (Feb 2020)
Genomic footprints of activated telomere maintenance mechanisms in cancer
- Lina Sieverling,
- Chen Hong,
- Sandra D. Koser,
- Philip Ginsbach,
- Kortine Kleinheinz,
- Barbara Hutter,
- Delia M. Braun,
- Isidro Cortés-Ciriano,
- Ruibin Xi,
- Rolf Kabbe,
- Peter J. Park,
- Roland Eils,
- Matthias Schlesner,
- PCAWG-Structural Variation Working Group,
- Benedikt Brors,
- Karsten Rippe,
- David T. W. Jones,
- Lars Feuerbach,
- PCAWG Consortium
Affiliations
- Lina Sieverling
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Chen Hong
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Sandra D. Koser
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Philip Ginsbach
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Kortine Kleinheinz
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Barbara Hutter
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Delia M. Braun
- Faculty of Biosciences, Heidelberg University
- Isidro Cortés-Ciriano
- Department of Biomedical Informatics, Harvard Medical School
- Ruibin Xi
- School of Mathematical Sciences and Center for Statistical Science, Peking University
- Rolf Kabbe
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Peter J. Park
- Department of Biomedical Informatics, Harvard Medical School
- Roland Eils
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Matthias Schlesner
- Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ)
- PCAWG-Structural Variation Working Group
- Benedikt Brors
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Karsten Rippe
- Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant
- David T. W. Jones
- German Cancer Consortium (DKTK)
- Lars Feuerbach
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- PCAWG Consortium
- DOI
- https://doi.org/10.1038/s41467-019-13824-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.
