Journal of Translational Medicine (Dec 2012)

Impact of apoptotic adipose-derived mesenchymal stem cells on attenuating organ damage and reducing mortality in Rat sepsis syndrome induced by cecal puncture and ligation

  • Chang Chia-Lo,
  • Leu Steve,
  • Sung Hsin-Ching,
  • Zhen Yen-Yi,
  • Cho Chung-Lung,
  • Chen Angela,
  • Tsai Tzu-Hsien,
  • Chung Sheng-Ying,
  • Chai Han-Tan,
  • Sun Cheuk-Kwan,
  • Yen Chia-Hung,
  • Yip Hon-Kan

DOI
https://doi.org/10.1186/1479-5876-10-244
Journal volume & issue
Vol. 10, no. 1
p. 244

Abstract

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Abstract Background We tested whether apoptotic adipose-derived mesenchymal stem cells (A-ADMSCs) were superior to healthy (H)-ADMSCs at attenuating organ damage and mortality in sepsis syndrome following cecal ligation and puncture (CLP). Methods Adult male rats were categorized into group 1 (sham control), group 2 (CLP), group 3 [CLP + H-ADMSC administered 0.5, 6, and 18 h after CLP], group 4 [CLP + A-ADMSC administered as per group 3]. Results Circulating peak TNF-α level, at 6 h, was highest in groups 2 and 3, and higher in group 4 than group 1 (p Conclusions A-ADMSC therapy protected major organs from damage and improved prognosis in rats with sepsis syndrome.