VIVALDI Cohort Profile: Using linked, routinely collected data and longitudinal blood sampling to characterise COVID-19 infections, vaccinations, and related outcomes in care home staff and residents in England [version 2; peer review: 2 approved]

Maria Krutikov; Oliver Stirrup; David Bone; Borscha Azmi; Rachel Bruton; Laura Shallcross; May Lau; Chris Fuller; Shivika Rastogi; Juliet Low; Paul Moss; Gokhan Tut; Igor Monakhov; Andrew Copas; Douglas Fink; Andrew Hayward

Wellcome Open Research (Aug 2024)

VIVALDI Cohort Profile: Using linked, routinely collected data and longitudinal blood sampling to characterise COVID-19 infections, vaccinations, and related outcomes in care home staff and residents in England [version 2; peer review: 2 approved]

Maria Krutikov,
Oliver Stirrup,
David Bone,
Borscha Azmi,
Rachel Bruton,
Laura Shallcross,
May Lau,
Chris Fuller,
Shivika Rastogi,
Juliet Low,
Paul Moss,
Gokhan Tut,
Igor Monakhov,
Andrew Copas,
Douglas Fink,
Andrew Hayward

Affiliations

Maria Krutikov: ORCiD; Institute of Health Informatics, University College London, London, England, NW1 2DA, UK
Oliver Stirrup: ORCiD; Institute for Global Health, University College London, London, England, WC1N 1EH, UK
David Bone: Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, England, B15 2TT, UK
Borscha Azmi: Institute of Health Informatics, University College London, London, England, NW1 2DA, UK
Rachel Bruton: Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, England, B15 2TT, UK
Laura Shallcross: ORCiD; Institute of Health Informatics, University College London, London, England, NW1 2DA, UK
May Lau: Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, England, B15 2TT, UK
Chris Fuller: Institute of Health Informatics, University College London, London, England, NW1 2DA, UK
Shivika Rastogi: Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, England, B15 2TT, UK
Juliet Low: Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, England, B15 2TT, UK
Paul Moss: ORCiD; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, England, B15 2TT, UK
Gokhan Tut: Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, England, B15 2TT, UK
Igor Monakhov: UK Health Security Agency, London, SW1P 3JR, UK
Andrew Copas: Institute for Global Health, University College London, London, England, WC1N 1EH, UK
Douglas Fink: Division of Infection & Immunity, University College London, London, England, WC1E 6JF, UK
Andrew Hayward: ORCiD; Institute of Epidemiology & Health Care, University College London, London, England, WC1E 7HB, UK

Journal volume & issue: Vol. 8

Abstract

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VIVALDI (ISRCTN14447421) is a government-funded longitudinal open observational cohort study of staff and residents in care homes for older people in England. The study aimed to describe epidemiology (including seroprevalence) and immune responses to COVID-19 in a subset of care homes, in the context of extremely high mortality in this setting, in the first 12-18 months of the pandemic. Data linkage to routine health data was undertaken for all staff and residents and a subset of individuals who consented to sequential blood sampling to investigate SARS-CoV-2 immunity. This paper aims to describe the samples stored within the VIVALDI biobank and associated linked data, available for use by researchers. Over 70,000 individuals from 346 care homes were included in the data linkage cohort (1st March 2020–31st March 2023). 4971 samples from 2264 individuals (1415 staff, 827 residents) collected between 29th October 2020 and 10th March 2023 are stored. Amongst these samples, there was a maximum of seven per participant however, 217 (26.2%) residents and 551 (38.9%) staff participated in one round only. Key study findings include high COVID-19 seroprevalence among surviving residents, exceeding rates in community-dwelling peers. COVID-19 vaccinations generated robust immune responses in staff and residents which waned, supporting the need for booster vaccination, particularly in response to new variants. Prior infection significantly improved vaccine-induced immune responses, however protection from infection declined following Omicron variant emergence. This is a unique cohort of pre- and post-infection samples linked to data on COVID-19 infections, vaccinations, and outcomes. The cohort spans host immune response evolution to infection and vaccination in this rarely sampled population of frail older care home residents who are especially vulnerable to infection and severe outcomes. These samples can be used to investigate biological mechanisms behind disparate infection responses in older people and make a valuable contribution to research into ageing.

Published in Wellcome Open Research

ISSN: 2398-502X (Online)
Publisher: Wellcome
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://wellcomeopenresearch.org/

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