COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCES

Abstract

There are several methods for solving the problem of an adequate dosage form for the hydrophobic and poorly soluble pharmaceutical substances which comprise a structure modification, preparation of solid dispersion systems, a change in pH, the use of cosolvents and solubilizers introduction of substances in the formulation of lipid nature and complexation. In this review, special attention is paid to the preparation of nanostructured dosage form for these classes of drugs. Are examples of drugs used successfully in clinical practice the development of which applied these methods.

Keywords

• cosolvents
• solubilizers
• solid dispersions
• complexation
• nanosystems