Nature Communications (Dec 2022)
Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke
- Wenlu Li,
- Emiri T. Mandeville,
- Violeta Durán-Laforet,
- Norito Fukuda,
- Zhanyang Yu,
- Yi Zheng,
- Aaron Held,
- Ji-Hyun Park,
- Takafumi Nakano,
- Masayoshi Tanaka,
- Jingfei Shi,
- Elga Esposito,
- Wanting Niu,
- Changhong Xing,
- Kazuhide Hayakawa,
- Ignacio Lizasoain,
- Klaus van Leyen,
- Xunming Ji,
- Brian J. Wainger,
- Maria A. Moro,
- Eng H. Lo
Affiliations
- Wenlu Li
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Emiri T. Mandeville
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Violeta Durán-Laforet
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Norito Fukuda
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Zhanyang Yu
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Yi Zheng
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Aaron Held
- Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School
- Ji-Hyun Park
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Takafumi Nakano
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Masayoshi Tanaka
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Jingfei Shi
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Elga Esposito
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Wanting Niu
- Tissue Engineering Laboratories, VA Boston Healthcare System
- Changhong Xing
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Kazuhide Hayakawa
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Ignacio Lizasoain
- Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Hospital 12 de Octubre
- Klaus van Leyen
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- Xunming Ji
- Cerebrovascular Research Institute, XuanWu Hospital, Capital Medical University
- Brian J. Wainger
- Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School
- Maria A. Moro
- Neurovascular Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
- Eng H. Lo
- Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-35498-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural progenitors, thus improving outcomes after stroke.
