Journal of Inflammation Research (Jun 2024)
TIF1-γ Positive Dermatomyositis with Spontaneous Muscular Hematoma in the Context of Ovarian Cancer: A Novel Survival Case Report
Abstract
Zhu Yuan,1,* Chunyan Chen,1,* Shuai Zeng,2 Zhen Wang,1 Shili Zhong1 1Department of Intensive Care Medicine, Army Medical Center of PLA, Chongqing, People’s Republic of China; 2Department of Laboratory Pathology, Unit 32280 of the People’s Liberation Army, Leshan City, Sichuan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shili Zhong, Department of Intensive Care Medicine, Army Medical Center of PLA, No. 10 Changjiang Road, Yuzhong District, Chongqing, 400010, People’s Republic of China, Tel +86-18323087674, Email [email protected]: Dermatomyositis (DM) represents a group of inflammatory myopathies, with TIF1-γ positive DM strongly associated with malignancies. Spontaneous muscular hematoma in DM patients is exceedingly rare and often prognosticates a severe clinical outcome, especially in the context of concurrent malignancy.Case Presentation: We describe a novel survival case of a patient with TIF1-γ positive DM and an underlying ovarian tumor who developed a spontaneous muscular hematoma. Despite the traditionally poor prognosis of these conditions, the patient survived through a comprehensive treatment regimen. This included targeted chemotherapy for ovarian cancer (Carboplatin and Paclitaxel), alongside corticosteroids, immunoglobulins, and immunosuppressants for DM, as well as component blood transfusions, coagulation correction therapy to control hematoma, and integrated management: nutritional support, lung function exercise, volume management.Results: The integrated treatment strategy stabilized the patient’s condition and resolved the hematoma, a significant achievement given the usual high mortality rate of such complications.Conclusion: This case underscores the importance of a multidisciplinary approach in the early diagnosis and treatment of TIF1-γ positive DM with complex comorbidities, including spontaneous muscular hematoma and ovarian cancer. It highlights the potential for favorable outcomes with aggressive and coordinated treatment strategies.Keywords: dermatomyositis, TIF1-γ, spontaneous muscular hematoma, ovarian cancer, multidisciplinary treatment, survival
