Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli

Kevin W. Zhu; Shawn D. Burton; Maira H. Nagai; Justin D. Silverman; Claire A. de March; Matt Wachowiak; Hiroaki Matsunami

doi:10.1038/s41467-022-32267-3

Nature Communications (Sep 2022)

Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli

Kevin W. Zhu,
Shawn D. Burton,
Maira H. Nagai,
Justin D. Silverman,
Claire A. de March,
Matt Wachowiak,
Hiroaki Matsunami

Affiliations

Kevin W. Zhu: Department of Molecular Genetics and Microbiology, Duke University School of Medicine
Shawn D. Burton: Department of Biological Sciences, Lehigh University
Maira H. Nagai: Department of Molecular Genetics and Microbiology, Duke University School of Medicine
Justin D. Silverman: College of Information Science and Technology, Pennsylvania State University
Claire A. de March: Department of Molecular Genetics and Microbiology, Duke University School of Medicine
Matt Wachowiak: Department of Neurobiology, University of Utah School of Medicine
Hiroaki Matsunami: Department of Molecular Genetics and Microbiology, Duke University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-32267-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

Read online

Targeted spatial transcriptomics mapped olfactory receptor mRNAs to sections of the murine olfactory bulb to generate an interactive, statistical, 3D model of glomeruli locations and identify an ultra-sensitive receptor-odorant relationship.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal