Evaluation and correction of the estimate of renal function in a Cuban adult population

Abstract

Introduction: There are difficulties with the evaluation of renal function in the Cuban population. Objectives: To evaluate and correct the estimate of renal function in a Cuban adult population. Methods: Cross-sectional descriptive observational study. The universe was made up of all the adults who underwent blood laboratory tests at the Institute of Nephrology, Havana, Cuba, in the month of September 2022. The information was processed automatically (SPSS® version 21.0 and Excel). Frequency distribution analysis, Pearson's correlation analysis and a Student's t test for comparison of means were used to determine the relationship between the creatinine determination methods. Results: 349 subjects were included. Mean creatinine concentration by the traceable Isotope Dilution Mass Spectroscopy (IDMS) method was 0,24 mg/dL lower than the non-traceable automated method, and 0,29 mg/dL lower than the non-traceable manual method. The respective Pearson correlations were 0,989 and 0,988. With the correction, the differences were less than 0,01 mg/dl. Mean differences in estimated glomerular filtration rates exceeded 15 mL/min/1,73 m2BS and decreased to less than 0,74 mL/min/1,73 m2BS with correction. In 257 individuals, creatinine was measured by enzymatic method with slight differences with respect to the traceable IDMS. Conclusions: The differences in the measurements of creatinine concentrations and in the estimated glomerular filtration rates between the traceable and non-traceable IDMS methods are notorious. With the suggested correction, the differences in measurements and estimates are reduced.

Keywords

• creatinina
• cuba
• tasa de filtración glomerular.