The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

Abstract

Histone methylation regulates gene expression. Here, Salifou et al.show that KDM4A, a histone lysine demethylase, regulates RNA polymerase I-driven transcription in a PI3K dependent manner, therefore linking nutrients and growth factors availability to ribosomal RNA transcription.