Journal of Vascular Surgery Cases and Innovative Techniques (Sep 2019)
Persistent type IV hypersensitivity after cyanoacrylate closure of the great saphenous vein
Abstract
The VenaSeal (Medtronic, Minneapolis, Minn) cyanoacrylate closure system is a nonthermal technique for ablating saphenous veins using a proprietary n-butyl cyanoacrylate. One possible side effect is an allergic reaction to cyanoacrylate. We report the case of a 49-year-old woman treated with cyanoacrylate closure who developed a persistent type IV hypersensitivity reaction. The patient elected to have the vein excised, and the histologic features were consistent with a type IV hypersensitivity reaction. Keywords: VenaSeal, Hypersensitivity, Endovenous ablation, Varicose vein, Allergic reaction