Journal of Vascular Surgery Cases and Innovative Techniques (Sep 2019)

Persistent type IV hypersensitivity after cyanoacrylate closure of the great saphenous vein

  • Andrew D. Jones, MD,
  • Edward M. Boyle, MD,
  • Randy Woltjer, MD,
  • Jason P. Jundt, MD,
  • Adam N. Williams, MD

Journal volume & issue
Vol. 5, no. 3
pp. 372 – 374

Abstract

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The VenaSeal (Medtronic, Minneapolis, Minn) cyanoacrylate closure system is a nonthermal technique for ablating saphenous veins using a proprietary n-butyl cyanoacrylate. One possible side effect is an allergic reaction to cyanoacrylate. We report the case of a 49-year-old woman treated with cyanoacrylate closure who developed a persistent type IV hypersensitivity reaction. The patient elected to have the vein excised, and the histologic features were consistent with a type IV hypersensitivity reaction. Keywords: VenaSeal, Hypersensitivity, Endovenous ablation, Varicose vein, Allergic reaction