The structural basis of proton driven zinc transport by ZntB

Cornelius Gati; Artem Stetsenko; Dirk J. Slotboom; Sjors H. W. Scheres; Albert Guskov

doi:10.1038/s41467-017-01483-7

Nature Communications (Nov 2017)

The structural basis of proton driven zinc transport by ZntB

Cornelius Gati,
Artem Stetsenko,
Dirk J. Slotboom,
Sjors H. W. Scheres,
Albert Guskov

Affiliations

Cornelius Gati: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
Artem Stetsenko: Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Dirk J. Slotboom: Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Sjors H. W. Scheres: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
Albert Guskov: Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen

DOI: https://doi.org/10.1038/s41467-017-01483-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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The bacterial zinc transporter ZntB is important for maintaining zinc homeostasis and is mechanistically not well understood. Here, the authors present the cryo-EM structure of ZntB at 4.2 Å resolution, perform transport assays and propose a model for its Zn2+ transport mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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