Medicine in Microecology (Jun 2021)
A transomic cohort as a reference point for promoting a healthy human gut microbiome
- Zhuye Jie,
- Suisha Liang,
- Qiuxia Ding,
- Fei Li,
- Shanmei Tang,
- Dan Wang,
- Yuxiang Lin,
- Peishan Chen,
- Kaiye Cai,
- Xuemei Qiu,
- Qiang Li,
- Yunli Liao,
- Dongsheng Zhou,
- Heng Lian,
- Yong Zuo,
- Xiaomin Chen,
- Weiqiao Rao,
- Yan Ren,
- Yuan Wang,
- Jin Zi,
- Rong Wang,
- Hongcheng Zhou,
- Haorong Lu,
- Xiaohan Wang,
- Wei Zhang,
- Tao Zhang,
- Liang Xiao,
- Yang Zong,
- Weibin Liu,
- Huanming Yang,
- Jian Wang,
- Yong Hou,
- Xiao Liu,
- Karsten Kristiansen,
- Huanzi Zhong,
- Huijue Jia,
- Xun Xu
Affiliations
- Zhuye Jie
- BGI-Shenzhen, Shenzhen, China; Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark; Corresponding author. Building 11, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, China.
- Suisha Liang
- BGI-Shenzhen, Shenzhen, China
- Qiuxia Ding
- BGI-Shenzhen, Shenzhen, China
- Fei Li
- BGI-Shenzhen, Shenzhen, China
- Shanmei Tang
- BGI-Shenzhen, Shenzhen, China
- Dan Wang
- BGI-Shenzhen, Shenzhen, China
- Yuxiang Lin
- BGI-Shenzhen, Shenzhen, China
- Peishan Chen
- BGI-Shenzhen, Shenzhen, China
- Kaiye Cai
- BGI-Shenzhen, Shenzhen, China
- Xuemei Qiu
- BGI-Shenzhen, Shenzhen, China
- Qiang Li
- BGI-Shenzhen, Shenzhen, China
- Yunli Liao
- BGI-Shenzhen, Shenzhen, China
- Dongsheng Zhou
- BGI-Shenzhen, Shenzhen, China
- Heng Lian
- BGI-Shenzhen, Shenzhen, China
- Yong Zuo
- BGI-Shenzhen, Shenzhen, China
- Xiaomin Chen
- BGI-Shenzhen, Shenzhen, China
- Weiqiao Rao
- BGI-Shenzhen, Shenzhen, China
- Yan Ren
- BGI-Shenzhen, Shenzhen, China
- Yuan Wang
- BGI-Shenzhen, Shenzhen, China
- Jin Zi
- BGI-Shenzhen, Shenzhen, China
- Rong Wang
- BGI-Shenzhen, Shenzhen, China
- Hongcheng Zhou
- China National Genebank, BGI-Shenzhen, Shenzhen, 518120, China
- Haorong Lu
- China National Genebank, BGI-Shenzhen, Shenzhen, 518120, China
- Xiaohan Wang
- BGI-Shenzhen, Shenzhen, China
- Wei Zhang
- BGI-Shenzhen, Shenzhen, China
- Tao Zhang
- BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark
- Liang Xiao
- BGI-Shenzhen, Shenzhen, China; Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI-Shenzhen, Shenzhen, China; BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China
- Yang Zong
- BGI-Shenzhen, Shenzhen, China
- Weibin Liu
- BGI-Shenzhen, Shenzhen, China
- Huanming Yang
- BGI-Shenzhen, Shenzhen, China; James D. Watson Institute of Genome Sciences, Hangzhou, China
- Jian Wang
- BGI-Shenzhen, Shenzhen, China; James D. Watson Institute of Genome Sciences, Hangzhou, China
- Yong Hou
- BGI-Shenzhen, Shenzhen, China
- Xiao Liu
- BGI-Shenzhen, Shenzhen, China
- Karsten Kristiansen
- BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark; BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China
- Huanzi Zhong
- BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark
- Huijue Jia
- BGI-Shenzhen, Shenzhen, China; Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark; Corresponding author. Building 11, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, China.
- Xun Xu
- BGI-Shenzhen, Shenzhen, China; Corresponding author.
- Journal volume & issue
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Vol. 8
p. 100039
Abstract
More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics data need to be measured to better understand the gut microbiome. Here, we present a cohort including 2183 adults with high-depth metagenomic shotgun sequencing data for the fecal microbiome and other omics data. In this multiomic cohort, we observe a number of vitamins, hormones, amino acids, and trace elements that correlated with the gut microbiome. Many of the associations are validated in an additional cohort consisting of 1404 individuals. Our comprehensive data are poised to provide advice to future populations and mechanistic study designs to better understand and manage our gut microbiome.
