Nature Communications (Feb 2023)
An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson’s disease participants
- Deborah A. Hall,
- Robin M. Voigt,
- Thaisa M. Cantu-Jungles,
- Bruce Hamaker,
- Phillip A. Engen,
- Maliha Shaikh,
- Shohreh Raeisi,
- Stefan J. Green,
- Ankur Naqib,
- Christopher B. Forsyth,
- Tingting Chen,
- Richard Manfready,
- Bichun Ouyang,
- Heather E. Rasmussen,
- Shahriar Sedghi,
- Christopher G. Goetz,
- Ali Keshavarzian
Affiliations
- Deborah A. Hall
- Department of Neurological Sciences, Rush University Medical Center
- Robin M. Voigt
- Department of Internal Medicine, Rush University Medical Center
- Thaisa M. Cantu-Jungles
- Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center
- Bruce Hamaker
- Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center
- Phillip A. Engen
- Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center
- Maliha Shaikh
- Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center
- Shohreh Raeisi
- Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center
- Stefan J. Green
- Department of Internal Medicine, Rush University Medical Center
- Ankur Naqib
- Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center
- Christopher B. Forsyth
- Department of Internal Medicine, Rush University Medical Center
- Tingting Chen
- Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University
- Richard Manfready
- Department of Internal Medicine, Rush University Medical Center
- Bichun Ouyang
- Department of Neurological Sciences, Rush University Medical Center
- Heather E. Rasmussen
- Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center
- Shahriar Sedghi
- Department of Medicine, Mercer University
- Christopher G. Goetz
- Department of Neurological Sciences, Rush University Medical Center
- Ali Keshavarzian
- Department of Internal Medicine, Rush University Medical Center
- DOI
- https://doi.org/10.1038/s41467-023-36497-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
This study found that a prebiotic intervention was well-tolerated and safe, beneficially changed the microbiome, decreased inflammation and a marker of neurodegeneration, with possible clinical effects in Parkinson’s disease (PD) patients. This study offers the rationale for further investigations using prebiotic fibers in PD.
